Editorial summary

The company is seeking a highly motivated Postdoctoral Fellow to lead and contribute to projects focused on therapeutic target discovery and translational development for metabolic dysfunction-associated steatotic hepatitis (MASH), with an emphasis on siRNA-based therapeutics. The role involves integrating patient-derived multi-omics datasets with in vivo functional genetic screening and human in vitro disease models to identify and validate clinically relevant targets. Key requirements include expertise in therapeutic target discovery, translational research, and a strong background suitable for driving siRNA-based therapeutic initiatives. Compensation is listed at 9,500.

This summary is AI-generated and may contain inaccuracies. Please refer to the full job description below.

Job description

[This job https://singapore.job-q.com/jobs/detail/scientist-laboratory-of-precision-disease-therapeutics-gis-37155 first appeared in Job-Q.com on 10 Oct 2026]

Position Overview

The Laboratory of Precision Disease Therapeutics focuses on therapeutic target discovery and translational development for metabolic dysfunction-associated steatotic hepatitis (MASH), with a strong emphasis on siRNA-based therapeutics.

Our research integrates patient-derived multi-omics datasets with in vivo functional genetic screening and human in vitro disease models to systematically identify and validate clinically relevant therapeutic targets.

We are seeking a highly motivated Postdoctoral Fellow to lead and contribute to projects involving therapeutic target validation, disease modeling, and translational therapeutic development.

The successful candidate will work in a highly interdisciplinary and translational research environment and is expected to contribute scientifically through experimental design, data interpretation, troubleshooting, and project development.

Requirements

• Design and execute independent research projects related to MASH and siRNA therapeutics
• Perform molecular and cellular biology experiments, including gene perturbation studies and disease modeling
• Contribute to in vivo studies and functional validation experiments
• Analyze and interpret experimental data and present findings in internal and external meetings
• Participate in manuscript preparation, grant applications, and collaborative projects
• Contribute to scientific discussions, troubleshooting, and project strategy development
• Mentor junior lab members when appropriate

Requirements

• PhD degree in Biomedical Sciences, Molecular Biology, Pharmacology, or related fields

• Strong background in molecular biology, cell biology, or translational disease research
• Experience with mammalian primary cell culture and molecular techniques
• Ability to independently plan and execute experiments
• Strong scientific reasoning, communication, and problem-solving skills
• Ability to work collaboratively in a fast-paced research environment

Preferred Qualifications (Not Required but Advantageous)

• Experience in liver disease, metabolic disease, or fibrosis research
• Experience with siRNA or gene knockdown approaches
• Experience with in vivo mouse studies
• Familiarity with histology or imaging-based assays
• Experience working in translational or interdisciplinary research settings
• Publication record in relevant research areas

Interested candidates are invited to send a cover letter stating your research interests and experience, curriculum vitae, and the names and email addresses of three references to:

LEE Yong-An ()

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Scam prevention reminder: You should not make any pre-payment when applying for any job.

Illegal practices reminder: It is illegal for recruiter to collect payment (kickback) from the worker https://www.mom.gov.sg/-/media/mom/documents/publications/foreign-workers/what-are-kickbacks.pdf